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(idiomatic) Despite, irrespective of, notwithstanding. quotations examples
No evening I had passed at Bly had the portentous quality of this one; in spite of which—and in spite also of the deeper depths of consternation that had opened beneath my feet—there was literally, in the ebbing actual, an extraordinarily sweet sadness.
1898, Henry James, The Turn of the Screw, Courier Dover Publications, published 1991, page 72